Chronic Infections & Biofilm
What are biofilms?
Biofilms are complex, adherent microecosystems that
potentially contain many types of organisms,
architectural features & structural building blocks.
Direct visualization of biofilms via fluorescence microscopy has demonstrated the presence of two dominant
constituents: cell bodies, consisting of organisms in different physiological & nutrient states & the extracellular
polymeric substance (EPS), the glue that holds the microbial community together & acts as a barrier to chemicals &
anti-microbial agents & inhibits immune responses
potentially contain many types of organisms,
architectural features & structural building blocks.
Direct visualization of biofilms via fluorescence microscopy has demonstrated the presence of two dominant
constituents: cell bodies, consisting of organisms in different physiological & nutrient states & the extracellular
polymeric substance (EPS), the glue that holds the microbial community together & acts as a barrier to chemicals &
anti-microbial agents & inhibits immune responses
Biofilm Associated Infections
The infectious biofilms attached to living (tissues) and nonliving (indwelling medical devices) surfaces can trigger
inflammation in the human body, which is a specific form of persistent infection. The biofilms have evolved
significantly increased antibiotic resistance relative to their free-floating counterparts, severely hampering the
successful treatment of biofilm-associated infections.
inflammation in the human body, which is a specific form of persistent infection. The biofilms have evolved
significantly increased antibiotic resistance relative to their free-floating counterparts, severely hampering the
successful treatment of biofilm-associated infections.
Biofilms: A New Hideout for Borrelia?
The role of bacterial biofilms in chronic infections
Targeting Biofilm
Dapsone is a novel and effective “persister” drug where classical antibiotic protocols have failed . . .
Lumbrokinase is an enzyme produced by earthworms. It is commonly used for
breaking up biofilm by dissolving the fibrin.
The most significant features of Serrapeptase is that it does not harm any
living cells or tissues in the human body; it only dissolves non-living tissue
such as cysts, hard and soft arterial plaque and blood clots etc.